Gene information
Official symbol FAP
Official full name fibroblast activation protein alpha
Gene type protein-coding gene
Chromosome2q24.2
Alias symbolDPPIV
Gene familyDASH family
Resources
Entrez Gene 2191
HGNC HGNC:3590
Ensembl ENSG00000078098
Vega OTTHUMG00000153890
UCSC uc002ucd.3
GO terms: 46 records
GO Description Category LogP Number of genes Detail
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001667 ameboidal-type cell migration GO Biological Processes -17.0771232 40 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0002020 protease binding GO Molecular Functions -28.8254555 31 More
GO:0004175 endopeptidase activity GO Molecular Functions -25.2809598 44 More
GO:0004252 serine-type endopeptidase activity GO Molecular Functions -24.0834770 30 More
GO:0005178 integrin binding GO Molecular Functions -20.5409412 26 More
GO:0005925 focal adhesion GO Cellular Components -8.40302345 46 More
GO:0008233 peptidase activity GO Molecular Functions -21.0463733 46 More
GO:0008236 serine-type peptidase activity GO Molecular Functions -23.9716175 31 More
GO:0008238 exopeptidase activity GO Molecular Functions -3.53660715 7 More
GO:0008283 cell population proliferation GO Biological Processes -17.2298624 68 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0010631 epithelial cell migration GO Biological Processes -10.0481870 21 More
GO:0010712 regulation of collagen metabolic process GO Biological Processes -14.4967625 19 More
GO:0010715 regulation of extracellular matrix disassembly GO Biological Processes -5.83914312 5 More
GO:0010716 negative regulation of extracellular matrix disassembly GO Biological Processes -6.84560710 4 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0017171 serine hydrolase activity GO Molecular Functions -24.8900503 32 More
GO:0030027 lamellipodium GO Cellular Components -1.61995196 15 More
GO:0030055 cell-substrate junction GO Cellular Components -9.04790297 48 More
GO:0030163 protein catabolic process GO Biological Processes -2.20136577 18 More
GO:0030193 regulation of blood coagulation GO Biological Processes -37.6853179 30 More
GO:0031252 cell leading edge GO Cellular Components -1.97716247 28 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0042803 protein homodimerization activity GO Molecular Functions -14.2815375 77 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043542 endothelial cell migration GO Biological Processes -10.6625063 19 More
GO:0045177 apical part of cell GO Cellular Components -8.17813885 46 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0050673 epithelial cell proliferation GO Biological Processes -5.54644403 9 More
GO:0050818 regulation of coagulation GO Biological Processes -40.0839917 32 More
GO:0050839 cell adhesion molecule binding GO Molecular Functions -14.4506551 68 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0051129 negative regulation of cellular component organization GO Biological Processes -13.1016989 75 More
GO:0051917 regulation of fibrinolysis GO Biological Processes -20.6622986 13 More
GO:0061041 regulation of wound healing GO Biological Processes -35.8633788 36 More
GO:0090130 tissue migration GO Biological Processes -11.7623300 24 More
GO:0090132 epithelium migration GO Biological Processes -9.75855830 21 More
GO:1900046 regulation of hemostasis GO Biological Processes -39.0044157 31 More
GO:1903034 regulation of response to wounding GO Biological Processes -34.9293555 38 More
GO:1903053 regulation of extracellular matrix organization GO Biological Processes -8.17680088 15 More
GO:1903054 negative regulation of extracellular matrix organization GO Biological Processes -8.11586193 6 More
GO:1905368 peptidase complex GO Cellular Components -4.61293625 9 More
Drug-Gene interaction
view
Related drugs: 1 record
Drug name Interaction type Source PMID View
talabostat TTD view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
prolyl endopeptidase FAP proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Tillmanns J et al. Int J Cardiol. 2017
All rights reserved: Soochow University Center for Systems Biology